Advancement in artificial intelligence (AI) technologies is set to confront society, alter our ways of practice, and disrupt long-standing notions and boundaries of professional responsibility and accountability in healthcare. In response, the Professionalism and Ethics Committee under the Hong Kong Academy of Medicine established a “Task Force on AI” to look into concomitant ethical and legal implications with a view to promoting the safe, effective, and responsible adoption of these technologies. Here, the author will map out some of the pertinent issues, from the impact of AI on the traditional doctor-patient relationship and regulatory framework to medico-legal liabilities, research, equity, and distributive justice. The emphasis is on exploring how postgraduate training, our standard of practice, and public policy may evolve to help navigate this future landscape of enormous promises and challenges.