Implementation of a nurse-led intravitreal injection service is a pivotal initiative to address the escalating demand for timely, cost-effective and accessible ophthalmic care. Central to establishing this service is ensuring safety at every step. The talk provides insights into upholding high competency standards, selecting suitable patients based on evidence-based criteria, fostering informed patient participation, and establishing protocols for managing adverse events. These strategies are essential for meeting the evolving needs of ophthalmology practice and enhancing patient outcomes.