Hospital buildings can play a key role in the healing experience of patients. In recent years, hospital planners and architects are adopting the approach of salutogenesis increasingly to design a healthcare milieu that promotes health and enhances patient restoration. It involves supporting patients with General Resistance Resources (GRR) to promote a positive Sense of Coherence (SOC). Salutogenic architectural design covers three main domains: comprehensibility, manageability, and meaningfulness. The three domains address the congnitive, behavioural, and affective needs of the patients. The salutogenic benefits will not only be confined to the patients, but is also highly relevant to the healthcare workers who many are facing burnout situations. Using the example of CUHK Medical Centre, a newly completed private teaching hospital in Hong Kong, the presentation will illustrate how salutogenic principles are applied in the design of a healthcare facility.