Authors (including presenting author) :
Tong HF(1)(2), Tang MHY(1)(2), Chong YK(1)(2).
Affiliation :
(1) Toxicology Reference Laboratory, Hong Kong Poison Control Centre, United Christian Hospital, Kowloon
(2) Department of Pathology, Princess Margaret Hospital
Introduction :
The evolving landscape of new psychoactive substances (NPS) poses a significant threat to public health, with these substances frequently circumventing legal restrictions and complicating clinical management due to their structural analogues of traditional drugs. Understanding local trends in NPS use is crucial in furthering the multi-pronged anti-drug efforts in Hong Kong.
Objectives :
In this study, we aimed to examine the prevalence and patterns of NPS use in a clinical laboratory setting, analyzing the associated clinical presentations and toxicological findings.
Methodology :
We conducted a retrospective review of positive NPS cases identified in a tertiary clinical toxicology center. Data were collated, including demographic information, clinical manifestations, and toxicology results, to elucidate trends and implications for patient care.
Result & Outcome :
A diverse array of NPS types including ketamine analogues, synthetic cathinones, synthetic cannabinoids, and synthetic opioids are identified in the review. Clinical presentations often involved severe neuropsychiatric symptoms, with a notable percentage of cases requiring hospital and intensive care unit admission. Co-ingestion of other substances was a common finding, augmenting the complexity of clinical management. Fatalities were recorded, with certain NPS linked to a higher risk of severe outcomes. The trend of NPS use in the locality is on the rise, with a substantial impact on public health reflected by the severity of clinical outcomes and the need for intensive medical care. The findings underscore the need for ongoing vigilance and proactive strategies among healthcare professionals. Enhancements in laboratory detection capabilities and awareness initiatives are essential in combating the challenges posed by the dynamic nature of NPS use.
